生命環境学群生物学類人間生物コース4年生の神谷沙羅さんが、卒業研究生として当研究室に参加しました。

〇神谷沙羅さん(生命環境学群生物学類4年)

　2023年4月より、解剖学・神経科学研究室にて卒業研究を行わせていただくことになりました、生物学類の神谷沙羅と申します。よろしくお願いいたします。

　私は高校生の頃、人間という生物の、特に脳について漠然とした興味を持ち始めました。進学先を考えるうちに、人間を生物学的に理解するという目標を掲げた人間生物コースという存在を知り、筑波大学の生物学類への進学を志しました。

　大学生となり、様々な講義を受ける中で、人間において、胎児が正常に生まれてこなくなってしまう原因やその仕組みに興味を持つようになりました。元より脳や免疫に興味があったこともあり、母体免疫反応の活性化が胎児の脳に与える影響について研究されている、こちらの解剖学・神経科学研究室で卒業研究を行う運びとなりました。

ご迷惑をおかけすることもあるかと思いますが、ご指導ご鞭撻のほどよろしくお願いいたします。

Publications

• Kubo A, Kamiya S, Sasaki T. Effects of Maternal Immune Activation and IL-17A on Abortion. BIO Clinica. 2024-09. 39(10): 38-40.
• Kamiya S, Sanaka S, Kubo A, Higuchi K, Kishi K, Sasaki T. IL-17: A Bridge from Psoriasis to Autism. Precision Medicine. 2024-09. Vol.7 No.11. 35-36. 
• Nakamura K, Kamiya S, Sasaki T. Molecular Basis of Neural Circuits Specific to the Prefrontal Cortex in Primates. THE CELL. 2024-08. 56(10): 65-66. 
• Kamiya S, Takei Y, Iwata S, Sasaki T. IL-17A mRNA expression in the cerebral cortex during postnatal development and its alternations in an animal model of ASD. Tsukuba Journal of Biology. 2024. 23(1): 42-42.
• Kamiya S, Kubo A, Higuchi K, Nakamura K, Kishi K, Sasaki T. Maternal immune activation and abortion: The Role of IL-17A. Reproductive Immunology and Biology. 2024-12. in press.
• Kamiya S, Sasaki T. Fetal Environment and Neurodevelopment: The Role of Maternal Immune System and Microbiota in Autism Spectrum Disorder Reproductive Immunology and Biology. 2024-12. in press.
• Kubo A, Kamiya S, Higuchi K, Nakamura K, Sanaka K, Sasaki T. How Does Maternal Immune Activity Affect Fetal Survival and Brain Development?: The critical roles of IL-17A and microglia. Jxiv. 2024.
• Higuchi K , Nakamura K, Kubo A , Sanaka S , Kamiya S, Sasaki T. Cytoskeletal and Motor Abnormalities in Schizophrenia and ASD. Jxiv. 2024.
• Kamiya S, Sasaki T. Fetal Environment and Neurodevelopment: The Role of Maternal Immune System and Microbiota in Autism Spectrum Disorder. Jxiv. 2024.
• Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. Elucidating the Pathogenic Mechanisms of Autism Spectrum Disorder Using Brain Organoids: Assessment of Environmental Factors and Challenges. 2024-09. Jxiv.
• Kubo A, Kamiya S, Higuchi K, Nakamura K, Sanaka S, Sasaki T. Prenatal Valproic Acid Exposure and Autism Spectrum Disorder: An Integrative Review of Developmental Neurotoxicity Mechanisms and Animal Models. 2024-09. Jxiv.
• Sasaki T, Nakamura K, Sanaka S, Higuchi K, Kamiya S, Kubo A. Anatomia Nova: The Evolution and Prospects of Anatomy in the Era of Human Augmentation Technology – An Integrative Review of Structure, Function, and Ethics. 2024-10. Jxiv.
• Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. From Sensory Quirks to Superhuman Tech: Pioneering Support Strategies for Autism Spectrum Disorder. 2024-10. Jxiv.
• Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. Autism Research Using Brain Organoids: Environmental Factors and Genetic Background. 2024-12. Struc Func. in press.
• Nakamura K, Kamiya S, Sasaki T. Laboratory Exercises in Laboratory of Anatomy&Neuroscience. Bulletin in Touikai. 2024. 65: 65-66.
• Sasaki T, Kamiya S, Nakamura K. Introduction of Laboratory: Laboratory of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba. Bulletin in Touikai. 2024. 65: 61-64.
• Sasaki T, Kubo A, Kamiya S, Higuchi K, Nakamura K. Enhanced maternal ROR γt enhances the effect of poly (I:C) in inducing fetal loss. Reproductive Immunology and Biology. 2024. 39(1): in press.
• Higuchi K, Kubo A, Kamiya S, Nakamura K, Sanaka S, Sasaki T. The Interplay of Psoriasis, Autism Spectrum Disorder, and Allergic Diseases: An Integrative Review of Pathogenic Mechanisms. in press.
• Kamiya S, Kubo A, Higuchi K, Kishi K, Sasaki T. Maternal Immune Activation as an Environmental Factor in Autism: Perspectives from the DoHAD Theory. 2024.  in press.

Presentation

Tetsuya Sasaki, Asumi Kubo, Sara Kamiya, Koki Higuchi, Kenyu Nakamura. Maternal ROR γt enhances the effect of poly (I:C) in inducing fetal loss. The 39th Annual Meeting of Japan Society for Immunology of Reproduction. 2024.12.13-14. Toyama. 

Koki Higuchi, Sara Kamiya, Asumi Kubo, Kenyu Nakamura, Kyoko Kishi, Momo Morikawa, Suguru Iwata. Yosuke Takei, Tetsuya Sasaki. Increased maternal expression of retinoic acid-related orphan receptor-γt intensifies the incidence of miscarriage triggered by polyinosinic–polycytidylic acid. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Koki Higuchi, Kyoko Kishi, Yosuke Takei. Tetsuya Sasaki. Distribution of IL-17RA mRNA in the developing cortex and its changes in animal models of ASD. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Kenyu Nakamura, Asumi Kubo, Sara Kamiya,Kyoko Kishi, Koki Higuchi, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei.  Analysis of the subcellular localization of the ASD risk gene Myosin Id. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Koki Higuchi, Tetsuya Sasaki. Dynamics of IL-17RA mRNA expression in the cerebral cortex and its alternations in animal models of ASD. The 12th Annual Meeting of The Japan Society of Developmental Origins of Health and Disease/ 2024-08-01–2024-08-03. Sapporo.

Sara Kamiya, Asumi Kubo, Koki Higuchi, Kenyu Nakamura, Tetsuya Sasaki. The role of IL-17A in the formation of the central nervous system and its abnormalities in autism spectrum disorders. The 12th Annual Meeting of The Japan Society of Developmental Origins of Health and Disease/ 2024-08-01–2024-08-03

Sara Kamiya, Koki Higuchi, Kenyu Nakamura, Kyoko Kishi, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei.  IL-17A mRNA expression in the cerebral cortex during postnatal development and its alternations in an animal model of ASD. The 129th Annual Meeting of The Japanese Association of Anatomists.

Yohei Soga, Suguru Iwata, Momo Morikawa, Tetsuya Sasaki, Sara Kamiya, Koki Higuchi, Yosuke Takei. Effects of antipsychotic drugs on microglia in a mouse model of schizophrenia. The 45th Annual Meeting of the Japanese Society of Biological Psychiatry (JSBP). 2023.11.06-07. Nago.

Tetsuya Sasaki, Sara Kamiya, Kyoko Kishi, Suguru Iwata, Satoru Takahashi, Yosuke Takei. Role of excessive immune molecule expression in psychiatric disorders. The 53rd Annual Meeting of the Japanese Society of Neuropsychopharmacology. 2023.09.07-09. Tokyo.

Tetsuya Sasaki, Sara Kamiya, Satoru Takahashi, Yosuke Takei. Cytokine balance modulation in psychiatric disorders. The 11th Developmental Origins of Health and Disease Research. 2023.08.04-05. Fukushima.

Tetsuya Sasaki, Sara Kamiya, Kyoko Kishi, Suguru Iwata, Yosuke Takei. IL-17A mRNA expression in the cerebral cortex during postnatal development and its alternations in an animal model of ASD. Neuroscience 2023. 2023.08.01-04. Sendai. 

Tetsuya Sasaki, Sara Kamiya, Kyoko Kishi, Suguru Iwata, Yosuke Takei. Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines. Neuroscience 2023. 2023.11.11-17. Washington D.C.

Tetsuya Sasaki, Sara Kamiya, Kyoko Kishi, Yosuke Takei, Tetsuo Yamamori. Specificity of dendritic spine morphology of pyramidal cells in primate prefrontal cortex. EMBO Workshop “Trans-Scale Biology”. 2023.07.25-28. Okazaki.

Sara Kamiya. IL-17A mRNA expression in the cerebral cortex during postnatal development and its alternations in an animal model of ASD. Graduation Thesis Presentation, College of Biology. 2024.02.19.

生命環境学群生物学類

人間生物コース