医学類学生、フロンティア医科学学位プログラム大学院生の英文総説が発行されました。研究は、タイムスパンが長い行為です。自分なりの短期の目標を設定し、フィードバックを意識しながら前進したいものです。発行まで約2年かかりました。無事に受理されてよかったです。

Sanaka S (左中彩恵), Kubo A, Kamiya S, Kenyu N. Sasaki T. Interleukin-17A (IL-17A): Molecular Characteristics and Its Physiological and Pathological Significance – From Molecular Structure to Clinical Applications. Receptors. 4(4). 2026-05. in press.

Abstract

Interleukin-17A (IL-17A) is a proinflammatory cytokine that plays a crucial role in immune responses and tissue homeostasis. The expression of IL-17A is strictly regulated by transcription factors including RORγt and is mainly produced by Th17 cells, γδT cells, and innate lymphoid cells. IL-17A signals through a heterodimeric receptor complex consisting of IL-17RA and IL-17RC, leading to the activation of NF-κB and MAPK pathways. Recent studies have highlighted its functions in the central nervous system, with reported associations with multiple sclerosis and autism spectrum disorder. Furthermore, the development of IL-17A inhibitors has progressed significantly, showing high therapeutic efficacy particularly in autoimmune diseases. This review provides an overview of current knowledge regarding IL-17A, from its molecular characteristics to clinical applications.

Keywords: cytokine receptors; IL-17A signaling; psychiatric disorders; Th17 cells; transcriptional regulation