生命環境学群 生物学類 人間生物コースの学生が参加2

生命環境学群生物学類人間生物コース3年生の久保明澄さんが、研究室に参加しました。

〇久保明澄さん(生命環境学群生物学類3年)

2024年4月より，こちらの研究室で卒業研究を行わせていただくことになりました，生物学類の久保と申します。どうぞよろしくお願いいたします。

私は高校生の頃から脳や神経に関して漠然と興味を持っており，それが理由で筑波大学の生物学類に入学しました。その後，人間生物コースに進み，フロンティア医科学のオープンキャンパスでこの研究室を見学した際に興味を持ち，主な研究内容を個人的に調べさせていただいたところ，特に妊娠中の母体内環境により仔の精神疾患リスクに影響が生じるという点に興味を引かれました。胎児期からの中枢神経系の発生に関して，生物学類で発生に関する講義・実験をいくつか受講するうちに関心が高まっていたこともあり，この研究室に所属させていただくことになりました。

ご迷惑をおかけしてしまうことも多々あるかもしれませんが，少しでも早く研究室での作業等に慣れていけるよう努力していきたいと思っております。ご指導のほど何卒よろしくお願いいたします。

所属学会：日本神経科学学会, 日本DoHAD学会, 日本コ・メディカル形態機能学会, 日本解剖学会

研究テーマ： “Spatiotemporal analysis of IL-17RA/RC expression in the cerebral cortex: examination of neuroimmunological links using a model of psychiatric disorders.”

生命環境学群生物学類人間生物コース→フロンティア医科学学位プログラム

Publications

Kamiya S, Sanaka S, Kubo A, Higuchi K, Nakamura K, Sasaki T. Multifaceted Potential of IL-17 Inhibitors: From Skin to Brain. 2025-03. Allergy and rheumatic diseases. Vol. 45. No.2. 72-73.

Kubo A, Kamiya S, Sasaki T. Effects of Maternal Immune Activation and IL-17A on Abortion. BIO Clinica. 2024. 39(10): 38-40.

Kamiya S, Sanaka S, Kubo A, Higuchi K, Kishi K, Sasaki T. L-17: A Bridge from Psoriasis to Autism. Precision Medicine. 2024-09. Vol.7 No.11. 35-36.

Kamiya S, Sanaka S, Kubo A, Higuchi K, Kishi K, Sasaki T. Psoriasis and ASD: Revolutionary Insights into Disease Mechanisms through IL-17. The Allergy in Practice. 2024-10. Vol. 44 No.12. 70-71.

Kubo A, Kamiya S, Higuchi K, Kishi K, Sasaki T. Maternal immune activation and abortion: The Role of Interleukin-17A. Reproductive Immunology and Biology. 2024. in press.

Kamiya S, Sanaka S, Kubo A, Higuchi K, Kishi K, Sasaki T. Psoriasis and ASD: Revolutionary Insights into Disease Mechanisms through IL-17. The Allergy in Practice. 2024-10. Vol. 38 No.1. 76-77.

Kubo A, Kamiya S, Higuchi K, Nakamura K, Sanaka S, Sasaki T. Prenatal Valproic Acid Exposure and Autism Spectrum Disorder: An Integrative Review of Developmental Neurotoxicity Mechanisms and Animal Models. 2024-12. DOHaD Research 12 (3). 15-24. in press.

Kamiya S, Kubo A, Higuchi K, Kishi K, Sasaki T. Maternal Immune Activation as an Environmental Factor in Autism: Perspectives from the DoHAD Theory. 2024. in press.

Higuchi K, Kubo A, Kamiya S, Nakamura K, Sanaka S, Sasaki T. The Interplay of Psoriasis, Autism Spectrum Disorder, and Allergic Diseases: An Integrative Review of Pathogenic Mechanisms. Clinical Immunology/ Allergy. 82(6) in press.

Kubo A, Kamiya S, Higuchi K, Nakamura K, Kishi K, Sasaki T. How Does Maternal Immune Activity Affect Fetal Survival and Brain Development?: The critical roles of IL-17A and microglia. Jxiv. 2024.

Kubo A, Sasaki T. L-17 signaling and neuroimmunology: Psoriasis to Autism Spectrum Disorder. Jxiv. 2024

Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. Elucidating the Pathogenic Mechanisms of Autism Spectrum Disorder Using Brain Organoids: Assessment of Environmental Factors and Challenges. 2024-09. Jxiv.

Kubo A, Kamiya S, Higuchi K, Nakamura K, Sanaka S, Sasaki T. Prenatal Valproic Acid Exposure and Autism Spectrum Disorder: An Integrative Review of Developmental Neurotoxicity Mechanisms and Animal Models. 2024-09. Jxiv.

Kubo A, Sanaka S, Shinoda N, Sasaki T. Development of a treatment for autism spectrum disorder that targets the brain’s immune system – A treatment strategy that controls synaptic pruning via microglia and the complement system -. 2025-01. Jxiv.

久保明澄, 佐々木哲也. 第12回日本DOHaD学会学術集会参加レポート. DOHaD研究. 2025-03. Vol.13 No.1 26-33.

Presentations

Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Koki Higuchi, Tetsuya Sasaki. Dynamics of IL-17RA mRNA expression in the cerebral cortex and its alternations in animal models of ASD. The 12th Annual Meeting of The Japan Society of Developmental Origins of Health and Disease/ 2024-08-01–2024-08-03. Sapporo.

Tetsuya Sasaki, Asumi Kubo, Sara Kamiya, Koki Higuchi, Kenyu Nakamura. The role of IL-17A in the formation of the central nervous system and its abnormalities in autism spectrum disorders. The 12th Annual Meeting of The Japan Society of Developmental Origins of Health and Disease/ 2024-08-01–2024-08-03. Sapporo.

Sara Kamiya, Asumi Kubo, Koki Higuchi, Kenyu Nakamura, Sae Sanaka, Tetsuya Sasaki. Maternal ROR γt enhances the effect of poly (I:C) in inducing fetal loss. The 39th Annual Meeting of Japan Society for Immunology of Reproduction. 2024.12.13-14. Toyama.

Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Koki Higuchi, Kyoko Kishi, Yosuke Takei. Tetsuya Sasaki. Distribution of IL-17RA mRNA in the developing cortex and its changes in animal models of ASD. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Asumi Kubo, Sara Kamiya, Koki Higuchi, Kenyu Nakamura, Sae Sanaka, Chikako Sakamoto, Momo Morikawa, Suguru Iwata, Yosuke Takei, Tetsuya Sasaki. Temporal and spatial mapping of IL-17 receptor expression in the cerebral cortex: Analysis using a psychiatric disease model. Anatomy-Physiology-Pharmacology Week in 2025 (APPW2025). 2025-03-17–2024-03-19. Makuhari.

Sae Sanaka, Sara Kamiya, Asumi Kubo, Kenyu Nakamura, Koki Higuchi, Chikako Sakamoto, Kyoko Kishi, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. IL-17A-mediated Neuroimmune Dysregulation in the CNS: Implications for Psychiatric Disease Pathogenesis. Anatomy-Physiology-Pharmacology Week in 2025 (APPW2025). 2025-03-17–2024-03-19. Makuhari.

Kenyu Nakamura, Koki Higuchi, Sae Sanaka, Chikako Sakamoto, Sara Kamiya, Asumi Kubo, Kyoko Kishi, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. Localization Properties and Regulatory Mechanisms of ASD Risk Factor Myosin Id in Neurons. Anatomy-Physiology-Pharmacology Week in 2025 (APPW2025). 2025-03-17–2024-03-19. Makuhari.