本日は、mRNAの品質管理異常に起因する免疫応答の活性化が行動的・電気生理学的異常を引き起こす論文について勉強しました。
Jennifer L.Johnson1227LoredanaStoica2327YuweiLiu1227Ping JunZhu12AbhisekBhattacharya45Shelly A.Buffington12RedwanHuq6N. TonyEissa45OlaLarsson7Bo T.Porse8910DeeptiDomingo11UrwahNawaz12ReneeCarroll12LachlanJolly12Tom S.Scerri13Hyung-GooKim14AmandaBrignell15Matthew J.Coleman16…MauroCosta-Mattioli12328
Neuron. 2019 Oct 1. pii: S0896-6273(19)30733-0. doi: 10.1016/j.neuron.2019.08.027. [Epub ahead of print]
Highlights
• Humans carrying novel variants in UPF2 exhibit speech and language deficits
• Upf2-deficient mice and flies have impaired NMD and exhibit behavioral deficits
• Inhibition of Upf2-dependent NMD triggers immune activation in mice
• Reduction of brain inflammation reverses synaptic and behavioral deficits

論文紹介:ST
