医学類の学生を筆頭著者とする下記の総説が、精神医学誌2025年7月号に掲載されます。スタッフの無茶ぶりに見事に応えて、M4のSさんが原稿と図を素早く仕上げてくれました。いつも迅速で丁寧な作業ありがとうございます (頼りになります)。おめでとうございます💐
Sanaka S, Sasaki T, Takei Y. Neuroimmune Interactions in Autism Spectrum Disorder: IL-17A-dependent Microglial Modulation and Pathophysiology. 2025-07. Clinical Psychiatry. 67(3): in press.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that develops as a result of the interaction of genetic and environmental factors. Maternal immune activation (MIA), a known environmental risk factor, significantly impacts fetal brain development via the production of inflammatory cytokines. Recently, the involvement of IL-17A signaling in the pathogenesis of ASD caused by MIA has been suggested. We found that IL-17A induces the activation and altered localization of microglia, immune cells in the brain, by administering IL-17A to the fetal brain. This change may induce abnormal cerebral cortex formation. In this review, we will outline the mechanism of ASD onset via IL-17A signaling, focusing on the functional transformation of microglia. We will also discuss the prospects for therapeutic strategies targeting the IL-17 pathway.
