医学群 医学類の学生が参加6

医学群医学類3年生の左中彩恵さんが研究室演習で研究室に参加しました！

〇左中彩恵さん(医学群医学類3年)

2024年度よりこちらの研究室に参加させていただくことになりました、医学類3年左中彩恵と申します。

以前より研究に興味があったものの怖気付いてしまい、また興味のある分野が定まらないこともありなかなか一歩を踏み出せずにいました。しかしM2の脳神経の発生学の講義や解剖実習を通してこんなにも複雑な脳の構造や神経回路がどのように発生発達していくのだろうととても不思議に思い、講義期間が終了した後ももっと知りたいという気持ちを抱き続けていました。そこで、このようにもっと知りたいと感じる分野に出会えたことをきっかけにやはり一度チャレンジしてみようとM3からの研究室演習の受講を決め、こちらの研究室で勉強させていただくことになりました。まだ実験には着手していませんがジャーナルクラブや輪読会での勉強を開始し、皆さんから日々刺激を受けています。これらを通して今まで全く知らなかった、精神疾患と母体免疫との関係性や精神疾患のメカニズムについて知るうちに興味の幅も広がるようになりました。今後は少しずつ実験にも取り組んでいきたいです。ご迷惑を沢山おかけするかと思いますが、真摯にひとつひとつ取り組んで参ります。

これからよろしくお願い致します。

所属学会：日本解剖学会

Publications

Sanaka S, Higuchi K, Nakamura K. Morikawa M, Iwata S, Sasaki T, Takei Y. Microstructural abnormalities of the cerebral cortex and autism spectrum disorders: from human pathology to animal models. Medical Science Digest. 2024-09. in press.

Kamiya S, Sanaka S, Kubo A, Higuchi K, Nakamura K, Sasaki T. Multifaceted Potential of IL-17 Inhibitors: From Skin to Brain. 2025-03. Allergy and rheumatic diseases. Vol. 45. No.2. 72-73.

Kamiya S, Sanaka S, Kubo A, Higuchi K, Kishi K, Sasaki T. IL-17: A Bridge from Psoriasis to Autism. Precision Medicine. 2024-09. Vol.7 No.11. 35-36.

Kamiya S, Sanaka S, Kubo A, Higuchi K, Nakamura K, Sasaki T. Psoriasis and ASD: Revolutionary Insights into Disease Mechanisms through IL-17. The Allergy in Practice. 2024-10. Vol. 38 No.1. 76-77.

Higuchi K, Kubo A, Kamiya S, Nakamura K, Sanaka S, Sasaki T. The Interplay of Psoriasis, Autism Spectrum Disorder, and Allergic Diseases: An Integrative Review of Pathogenic Mechanisms. Clinical Immunology/ Allergy. 82(6) in press.

Kubo A, Kamiya S, Higuchi K, Nakamura K, Sanaka S, Sasaki T. Prenatal Valproic Acid Exposure and Autism Spectrum Disorder: An Integrative Review of Developmental Neurotoxicity Mechanisms and Animal Models. 2024-12. DOHaD Research 12 (3). 15-24. in press.

Higuchi K, Nakamura K. Kubo A, Sanaka S, Kamiya S, Sasaki T. Abnormalities in Cytoskeleton and Molecular Motors in Psychiatric Disorders: Focus on Schizophrenia and Autism Spectrum Disorder. 2024-09. Jxiv.

Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. Elucidating the Pathogenic Mechanisms of Autism Spectrum Disorder Using Brain Organoids: Assessment of Environmental Factors and Challenges. 2024-09. Jxiv.

Kubo A, Kamiya S, Higuchi K, Nakamura K, Sanaka S, Sasaki T. Prenatal Valproic Acid Exposure and Autism Spectrum Disorder: An Integrative Review of Developmental Neurotoxicity Mechanisms and Animal Models. 2024-09. Jxiv.

Sasaki T, Nakamura K, Sanaka S, Higuchi K, Kamiya S, Kubo A. Anatomia Nova: The Evolution and Prospects of Anatomy in the Era of Human Augmentation Technology – An Integrative Review of Structure, Function, and Ethics. 2024-10. Jxiv.

Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. From Sensory Quirks to Superhuman Tech: Pioneering Support Strategies for Autism Spectrum Disorder. 2024-10. Jxiv.

Nakamura K, Sanaka S, Higuchi K, Kubo A, Kamiya S, Sasaki T. Autism Research Using Brain Organoids: Environmental Factors and Genetic Background. 2024-12. Struc Func. in press.

Sasaki T, Sanaka S, Kamiya S. Pharmacological Treatment of Autism Spectrum Disorder: Evidence and Clinical Decision Making in Practice. 2024-12. Jxiv.

Sanaka S, Sasaki T. Pharmacological Treatment of Autism Spectrum Disorder: Evidence and Clinical Decision-Making in Practice. Clinical Psychopharmacology. 2025-02. 28 (02). in press.

Sakamoto C, Sanaka S, Sasaki T, Takei Y. in submission.

Sanaka S, Sasaki T, Takei Y. Neuroimmune Interactions in Autism Spectrum Disorder: IL-17A-dependent Microglial Modulation and Pathophysiology. Clinical Psychiatry. 2025-03. 67(3): in press.

Kubo A, Sanaka S, Shinoda N, Sasaki T. Development of a treatment for autism spectrum disorder that targets the brain’s immune system – A treatment strategy that controls synaptic pruning via microglia and the complement system -. 2025-01. Jxiv.

左中彩恵. 解剖実習を終えて. つくば白菊. 2023-09. No.43. 7-8.

左中彩恵. 一歩踏み出した先にある世界-研究室演習で得た学びと気づき-. 桐医会会報. 2025-09. No.98. in press.

左中彩恵, 佐々木哲也, 武井陽介. 免疫-脳連関から見た自閉スペクトラム症の病態理解-IL-17Aによるミクログリア機能修飾の観点から-. 精神医学. 67(3): in press.

Presentations

Sara Kamiya, Asumi Kubo, Koki Higuchi, Kenyu Nakamura, Sae Sanaka, Tetsuya Sasaki. Maternal ROR γt enhances the effect of poly (I:C) in inducing fetal loss. The 39th Annual Meeting of Japan Society for Immunology of Reproduction. 2024.12.13-14. Toyama.

Koki Higuchi, Sara Kamiya, Asumi Kubo, Kenyu Nakamura, Sae Sanaka, Kyoko Kishi, Momo Morikawa, Suguru Iwata. Yosuke Takei, Tetsuya Sasaki. Increased maternal expression of retinoic acid-related orphan receptor-γt intensifies the incidence of miscarriage triggered by polyinosinic–polycytidylic acid. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Koki Higuchi, Sae Sanaka, Kyoko Kishi, Yosuke Takei. Tetsuya Sasaki. Distribution of IL-17RA mRNA in the developing cortex and its changes in animal models of ASD. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Kenyu Nakamura, Asumi Kubo, Sara Kamiya,Kyoko Kishi, Koki Higuchi, Sae Sanaka, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. Analysis of the subcellular localization of the ASD risk gene Myosin Id. The 112th Annual Meeting of the Kanto Branch of the Japanese Association of Anatomists. 2024. Tokyo.

Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Koki Higuchi, Sae Sanaka, Tetsuya Sasaki. Dynamics of IL-17RA mRNA expression in the cerebral cortex and its alternations in animal models of ASD. The 12th Annual Meeting of The Japan Society of Developmental Origins of Health and Disease/ 2024-10-13–2024-10-14. Sapporo.

Sara Kamiya, Asumi Kubo, Koki Higuchi, Kenyu Nakamura, Sae Sanaka, Tetsuya Sasaki. The role of IL-17A in the formation of the central nervous system and its abnormalities in autism spectrum disorders. The 12th Annual Meeting of The Japan Society of Developmental Origins of Health and Disease/ 2024-10-13–2024-10-14. Sapporo.

Asumi Kubo, Sara Kamiya, Koki Higuchi, Kenyu Nakamura, Sae Sanaka, Chikako Sakamoto, Momo Morikawa, Suguru Iwata, Yosuke Takei, Tetsuya Sasaki. Temporal and spatial mapping of IL-17 receptor expression in the cerebral cortex: Analysis using a psychiatric disease model. Anatomy-Physiology-Pharmacology Week in 2025 (APPW2025). 2025-03-17–2024-03-19. Makuhari.

Sae Sanaka, Sara Kamiya, Asumi Kubo, Kenyu Nakamura, Koki Higuchi, Chikako Sakamoto, Kyoko Kishi, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. IL-17A-mediated Neuroimmune Dysregulation in the CNS: Implications for Psychiatric Disease Pathogenesis. Anatomy-Physiology-Pharmacology Week in 2025 (APPW2025). 2025-03-17–2024-03-19. Makuhari.

Kenyu Nakamura, Koki Higuchi, Sae Sanaka, Chikako Sakamoto, Sara Kamiya, Asumi Kubo, Kyoko Kishi, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. Localization Properties and Regulatory Mechanisms of ASD Risk Factor Myosin Id in Neurons. Anatomy-Physiology-Pharmacology Week in 2025 (APPW2025). 2025-03-17–2024-03-19. Makuhari.

Sae Sanaka, Asumi Kubo, Sara Kamiya, Kenyu Nakamura, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. Analysis of the spatiotemporal expression of IL-17RA/RC in the cerebral cortex and neuro-immune interactions. 2025 1st Meeting of the Laboratory Exercise for the College of Medicine, School of Medicine and Health Sciences. 2025.04.18. Tsukuba.

Kenyu Nakamura, Sae Sanaka, Asumi Kubo, Sara Kamiya, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. Novel functions of axonal guidance molecules in neuronal morphogenesis in the cerebral cortex. 2025 1st Meeting of the Laboratory Exercise for the College of Medicine, School of Medicine and Health Sciences. 2025.04.18. Tsukuba.

Chikako Sakamoto, Sae Sanaka, Kenyu Nakamura, Asumi Kubo, Sara Kamiya, Momo Morikawa, Suguru Iwata, Tetsuya Sasaki, Yosuke Takei. IL-17RA protein localization in the cerebral cortex and abnormalities in the ASD model. 2025 1st Meeting of the Laboratory Exercise for the College of Medicine, School of Medicine and Health Sciences. 2025.04.18. Tsukuba.

Publications | 解剖学・神経科学研究室（武井研究室）

左中彩恵さんの「解剖実習を終えて」感想文が、令和5年度優秀作品に選ばれました。