Journal Club (February 22, 2021)


Prolonged anesthesia alters brain synaptic architecture (長時間の麻酔は脳のシナプス構造を変化させる)

Michael Wenzel, Alexander Leunig, Shuting Han, Darcy S. Peterka, and Rafael Yuste PNAS February 16, 2021 118 (7) e2023676118;

  1. Edited by Emery N. Brown, Massachusetts General Hospital, Boston, MA, and approved December 19, 2020 (received for review November 20, 2020)


In human patients, prolonged medically induced coma (pMIC) is associated with significant cognitive deficits. Yet, a synapse-level neuromorphological correlate has been demonstrated experimentally only in early life, when the brain is highly plastic. The current notion is that synapses become increasingly stabilized and that MIC has no effect on synaptic dynamics in adulthood. Yet, the longest experimental study of MIC-associated synaptic changes has been only ∼6 h. We established a pMIC experimental protocol in mice and found that pMIC alters synaptic brain architecture and object recognition at all ages. Our results ring an alarm bell to the medical community and call for the development of individually tailored anesthetic regimens and intensified research on adjuvant therapeutic strategies to maintain brain structure and function during pMIC.


adjuvant (アジュバント): アジュバントとは、薬物による効果を高めたり補助する目的で併用される物質・成分の総称である。


Prolonged medically induced coma (pMIC) is carried out routinely in intensive care medicine. pMIC leads to cognitive impairment, yet the underlying neuromorphological correlates are still unknown, as no direct studies of MIC exceeding ∼6 h on neural circuits exist. Here, we establish pMIC (up to 24 h) in adolescent and mature mice, and combine longitudinal two-photon imaging of cortical synapses with repeated behavioral object recognition assessments. We find that pMIC affects object recognition, and that it is associated with enhanced synaptic turnover, generated by enhanced synapse formation during pMIC, while the postanesthetic period is dominated by synaptic loss. Our results demonstrate major side effects of prolonged anesthesia on neural circuit structure.


Keywords: 麻酔、樹状突起スパイン、シナプス可塑性、記憶障害、二光子イメージング

*Rafael Yusteはコロンビア大学教授で、神経生物学者である。2013年に発表されたBRAINイニシアチブの創始者のひとりである。

*PNAS (Proceedings of the National Academy of Sciences of the United States of America: Proc. Natl. Acad. Sci. USA)は、1915年に創刊された米国科学アカデミー発行の機関誌である。



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