武井教授が東京大学大学院医学研究科　廣川信隆先生のラボに在籍していた時の研究が論文になりました。 武井教授が、研究室のジャーナルクラブでその詳細や研究の裏側を紹介しました。

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia‐like phenotypes in mice

Ashwaq Hassan Alsabban, Momo Morikawa, Yosuke Tanaka, Yosuke Takei, Nobutaka Hirokawa

EMBO J (2019) e101090 https://doi.org/10.15252/embj.2018101090

Altered synaptic surface expression of N-methyl-d-aspartate receptors (NMDARs) affects neuronal function and has been linked to schizophrenia. Here, the kinesin KIF3B is shown to transport NMDAR subunit 2A (NR2A) into neuronal dendrites, with its disruption causing schizophrenia-like phenotypes in mice.

• Kif3b^+/− mice exhibit schizophrenia-like behavioral phenotypes.
• KIF3B transports vesicles containing the NR2A complex into neuronal dendrites.
• A mutation in human Kif3b gene was identified in schizophrenia patients.
• The patient mutation-carrying KIF3B is functionally defective and cannot rescue Kif3b^+/− phenotypes.

https://www.embopress.org/doi/10.15252/embj.2018101090

廣川先生によるキネシンスーパーファミリー分子モーターのレビュー Kinesin superfamily motor proteins and intracellular transport Nobutaka Hirokawa, Yasuko Noda, Yosuke Tanaka & Shinsuke Niwa Nature Reviews Molecular Cell Biology volume 10, pages682–696(2009) https://www.nature.com/articles/nrm2774