総合科目
III 新しい基礎医学における神経科学と免疫研究
講義題目『精神・神経疾患とDNAメチル化』
担当：医学医療系 増田知之
下記講義内容リストのPDFダウンロードはこちら| #1 | セントラルドグマとヒトゲノム：ヒトゲノムの大きさ | 参考文献 | #2 | 3つの代表的な精神疾患について | 参考文献 | #3 | GWAS による精神疾患原因遺伝子の検索 | 参考文献 | #4 | セントラルドグマにとっての “不都合な真実”：missing heritability | 参考文献 | #5 | DNAメチル化発見の歴史：実は長い歴史をもつ | 参考文献 | #6 | DNAのどこがメチル化されるのか？：バイサルファイト法 | 参考文献 | #7 | DNAがメチル化されるとどうなるのか？ | #8 | DNAメチル化酵素の哺乳類における発現部位 | 参考文献 | #9 | 哺乳類（ヒト）におけるDNAメチル化の意義 | 参考文献 | #10 | メチル化以外のDNA修飾体の発見：第6〜8番目の “塩基” の登場 | 参考文献 | #11 | 精神疾患とDNAメチル化：双生児を用いた研究／死後脳を用いた研究 | 参考文献 | #12 | 死後脳を使用する際の利点と注意点：ニューロンとグリア／個体差 | 参考文献 | #13 | 神経変性疾患について | 参考文献 | #14 | 神経変性疾患とDNAメチル化：死後脳を用いた研究 | 参考文献 | #15 | 有機ヒ素による神経変性とDNAメチル化の研究：神栖市での有機ヒ素汚染 | 参考文献 | #16 | 総まとめ：脳は想像以上に脆弱。逃げるは恥だが役に立つ？ |
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参考文献リスト
下記文献リストのPDFダウンロードはこちら| 項目# | 著者名 | 発行年 | 雑誌名（出版社名・ウェブ名） | タイトル | ウェブアドレス | 1 | リッカルド・サバティーニ Riccardo Sabatini |
2016 | TED | ゲノムを読んで人間を作る方法 |
https://www.ted.com/talks/ riccardo_sabatini_how_to_ read_the_genome_and _build_a_human_being? language=ja |
2 | 厚生労働省 社会・援護局障害保健福祉部 |
2016 | 参考資料 - 厚生労働省 | 精神疾患を有する総患者数の推移 厚生労働省「患者調査」より |
http://www.mhlw.go.jp/file/ 05-Shingikai-12201000- Shakaiengokyokushougai hokenfukushibu-Kikakuka/ 0000108755_12.pdf |
3 | Ikeda M et al. | 2017 | Molecular Psychiatry, in press | A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder | CONVERGE consortium | 2015 | Nature 523, 588-591 | Sparse whole-genome sequencing identifies two loci for majordepressive disorder | 4 | Uher R | 2014 | Frontiers in Psychiatry 5: 48 | Gene-environment interactions in severe mental illness | 5 | Wyatt GR | 1950 | Nature 166, 237-238 | Occurrence of 5-methylcytosine in nucleic acids | Dunn DB, Smith JD | 1955 | Nature 175, 336-337 | Occurrence of a new base in the deoxyribonucleic acid of a strain of Bacterium coli | Gowher H et al. | 2000 | EMBO Journal 19, 6918-6923 | DNA of Drosophila melanogaster contains 5-methylcytosine | Lyko F et al. | 2000 | Nature 408, 538-539 | DNA methylation in Drosophila melanogaster | Heyn H, Esteller M | 2015 | Cell 161, 710-713 | An adenine code for DNA: A second life for N6-methyladenine | Zhang G et al. | 2015 | Cell 161, 893-906 | N6-methyladenine DNA modification in Drosophila | Greer EL et al. | 2015 | Cell 161, 868-878 | DNA methylation on N6-adenine in C. elegans | Fu Y et al. | 2015 | Cell 161, 879-892 | N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas | Wu TP et al. | 2016 | Nature 532, 329-333 | DNA methylation on N6-adenine in mammalian embryonic stem cells | 6 | Lister R et al. | 2009 | Nature 462, 315-322 | Human DNA methylomes at base resolution show widespread epigenomic differences | 8 | Goto K et al. | 1994 | Diferentiation 56, 39-44 | Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice | Feng J et al. | 2005 | Journal of Neuroscience Research79, 734-746 | Dynamic expression of de novo DNAmethyltransferases Dnmt3a and Dnmt3b in the central nervous system | 9 | 岡田典弘 | ラボウェブ | 東工大 岡田研究室 About us Group メカニズム班 | 転移因子とは？ | 岡田典弘 | ラボウェブ | 東工大 岡田研究室 Research Keywords | Aluとは・・・ | Hayakawa K et al. | 2012 | Mammalian Genome 23, 336-345 | Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily | 有馬隆博 | 2015 | 生命誌ジャーナル87号 | ヒトから知るエピジェネティクスと進化 |
http://www.brh.co.jp/ seimeishi/journal/087/ research/2.html |
10 | Edited by Brendy TW | 2017 | （出版社） Academic Press | DNA modifications in the brain | Szulwach KE et al. | 2011 | Nature Neurosience 14, 1607-1616 | 5-hmC-mediated epigenetic dynamics during postnatalneurodevelopment and aging | 11 | Sugawara H et al. | 2011 | Translational Psychiatry 1: e24 | Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins | 12 | Nedergaard M et al. | 2003 | Trends in Neuroscience 26(10):523-530. | New roles for astrocytes: redefining the functional architecture of the brain | Azevedo FAC et al. | 2009 | The Journal of Comparative Neurology 513, 532-541 | Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain | Iwamoto K et al. | 2011 | Genome Research 21, 688-696 | Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons | 13 | Alzheimer's Disease International | 2018 | World Alzheimer Report 2018 |
https://www.alz.co.uk/ research/world-report-2018 |
14 | Lunnon K et al. | 2014 | Nature Neuroscience 17, 1164-1170 | Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease | De Jager PL et al. | 2014 | Nature Neuroscience 17, 1156-1163 | Alzheimer's disease: early alterations in brain DNA methylation at ANK1,BIN1, RHBDF2 and other loci | Matsumoto L et al. | 2010 | PLoS ONE 5: e15522 | CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease | Iwata A et al. | 2014 | Human Molecular Genetics 23, 648-656 | Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation | 15 | Ishii K et al. | 2019 | European Journal of Neurology26(1), 136-141 | Decreased regional cerebral blood flow in patients with diphenylarsinic acid intoxication | Masuda T et al. | 2017 | Archives of Toxicology 91(8),2799-2812 | Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys | Mano T et al. | 2017 | PNAS 114(45), E9645-E9654 | Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease |
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